MARIEKE ROEFS, MSC.
Extracellular vesicles | Cell Biology | In vivo studies
My research is focused on unravelling extracellular vesicle (EV)-mediated cardioprotection. EVs are small, cell-derived lipid bilayer enclosed particles that play a role in intercellular communication. EVs secreted by cardiac progenitor cells (CPCs) have been shown to protect the myocardium against ischemia/reperfusion injury in several preclinical models. However, the underlying mechanisms for CPC-EV-mediated cardioprotection remain elusive. The aim of my PhD is to unravel the underlying mechanisms of the regenerative properties of CPC-EVs in the heart. Additionally, we focus on improving the application of CPC-EVs as therapeutic by studying their properties in different in vitro and in vivo models.
Ortega, F. G., Roefs, M. T., de Miguel Perez, D., Kooijmans, S. A., de Jong, O. G., Sluijter, J. P., Vader, P. (2019). Interfering with endolysosomal trafficking enhances release of bioactive exosomes. Nanomedicine: Nanotechnology, Biology, and Medicine, 20, 102014. https://doi.org/10.1016/j.nano.2019.102014