PIETER VADER PHD

Assistant Professor

Extracellular vesicles | Lipid nanoparticles | RNA therapeutics

Pieter Vader graduated in Chemistry (B.Sc., 2005) and Drug Innovation (M.Sc., 2007) from the University of Utrecht. He earned his PhD degree in 2012 from the University of Utrecht on the subject of targeted delivery of siRNA to inhibit tumor angiogenesis.

From 2012 to 2014, Pieter was employed as a (senior) postdoctoral fellow at the University of Oxford, UK, in the lab of Prof. Matthew Wood, supported by a NWO Rubicon fellowship. The research topic was development of small RNA-loaded extracellular vesicles for targeted delivery.

In 2014 he moved back to The Netherlands to continue his work at the University Medical Center Utrecht. Currently, he is Assistant Professor at CDL Research and at the Department of Experimental Cardiology. His main research interests are in the field of therapeutic applications of extracellular vesicles, including unraveling the mechanisms underlying extracellular vesicle-mediated cargo transfer. His research has been supported by a NWO VENI fellowship (2014), ERC Starting Grant (2019) and Dutch Heart Foundation Dekker Senior Scientist Grant (2019).

Key Publications:

de Jong OG, et al. A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA. Nat Commun. 2020;11(1):1113. doi:10.1038/s41467-020-14977-8

Russell AE, et al. Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop. J Extracell Vesicles. 2019;8(1):1684862. doi:10.1080/20013078.2019.1684862

Kooijmans SAA, et al. Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach. Nanoscale. 2018;10(5):2413‐2426. doi:10.1039/c7nr06966a

O'Loughlin AJ, et al. Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles. Mol Ther. 2017;25(7):1580‐1587. doi:10.1016/j.ymthe.2017.03.021


E-mail

pvader@umcutrecht.nl

 

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