Postdoctoral Researcher
Research: Sex Differences | In vitro systems | Immunology and Heart Failure Comorbidities

My research focus is the creation of sex-specific cardiac in vitro models to increase our understanding of molecular pathways involved in heart failure. We aim at investigating heart failure related comorbidities and their effect on various cell types, such as cardiomyocytes, fibroblasts, endothelial cells and inflammatory cells, such as monocytes and macrophages. Besides that, we aim at comparing the results translationally to data from male and female patients to validate our findings.


1.     Groepenhoff F, Bots SH, Kessler EL, Sickinghe AA, Eikendal ALM, Leiner T et al. Sex-Specific Aspects in the Pathophysiology and Imaging of Coronary Macro- and Microvascular Disease. Journal of Cardiovascular Translational Research. 2019 Aug 30. https://doi.org/10.1007/s12265-019-09906-0

2.     Kessler EL, Rivaud MR, Vos MA, van Veen TAB. Sex-specific influence on cardiac structural remodeling and therapy in cardiovascular disease. Biology of Sex Differences. 2019 Feb 4;10(1). 7. https://doi.org/10.1186/s13293-019-0223-0

3.     Sickinghe AA, Korporaal SJA, den Ruijter HM, Kessler EL. Estrogen Contributions to Microvascular Dysfunction Evolving to Heart Failure With Preserved Ejection Fraction. Frontiers in Endocrinology. 2019 Jul 3;10. 442. https://doi.org/10.3389/fendo.2019.00442

4.     Noorman M, Hakim S, Kessler E, Groeneweg JA, Cox MGPJ, Asimaki A et al. Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Heart Rhythm. 2013;10(3):412-419. https://doi.org/10.1016/j.hrthm.2012.11.018

5.     Kessler EL, van Stuijvenberg L, van Bavel JJA, van Bennekom J, Zwartsen A, Rivaud MR et al. Flotillins in the intercalated disc are potential modulators of cardiac excitability. Journal of Molecular and Cellular Cardiology. 2019 Jan 1;126:86-95. https://doi.org/10.1016/j.yjmcc.2018.11.007

6.     Kessler EL. Myocardial remodeling during pathophysiology: Relevance for cardiac dysfunction. Utrecht University, 2018. 235 p.

7.     Wang J-W, Fontes MSC, Wang X, Chong SY, Kessler EL, Zhang Y-N et al. Leukocytic toll-like receptor 2 deficiency preserves cardiac function and reduces fibrosis in sustained pressure overload. Scientific Reports. 2017 Dec 1;7(1). 9193. https://doi.org/10.1038/s41598-017-09451-3

8.     Kessler EL, Nikkels PGJ, van Veen TAB. Disturbed Desmoglein-2 in the intercalated disc of pediatric patients with dilated cardiomyopathy. Human Pathology. 2017 Sep 1;67:101-108. https://doi.org/10.1016/j.humpath.2017.07.012

9.     Kessler EL, van Veen TAB. A fishing trip to cure arrhythmogenic cardiomyopathy? Annals of Translational Medicine. 2015;3(7):90. https://doi.org/10.3978/j.issn.2305-5839.2015.01.36

10.   Fontes MSC, Kessler EL, van Stuijvenberg L, Brans MA, Falke LL, Kok B et al. CTGF knockout does not affect cardiac hypertrophy and fibrosis formation upon chronic pressure overload. Journal of Molecular and Cellular Cardiology. 2015 Nov;88:82-90. https://doi.org/10.1016/j.yjmcc.2015.09.015

11.   Zhang S-S, Kuhn DA, Kessler EL, Asimaki A, Sottas V, Vanhecke D et al. Arrhythmogenic Cardiomyopathy Mutations Cause Disassembly of the Cx43 Forward Trafficking Machinery Which Can Be Rescued by GSK-3beta Inhibition. 2014. Abstract from 2014 Scientific Sessions American Heart Association, Chicago, IL, United States.

12.   Kessler EL, Boulaksil M, van Rijen HVM, Vos MA, van Veen TAB. Passive ventricular remodeling in cardiac disease: focus on heterogeneity. Frontiers in Physiology [E]. 2014;5. 482. https://doi.org/10.3389/fphys.2014.00482

E-mail: E.L.Kessler@umcutrecht.nl


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